Lub mechanism ntawm kev txiav txim ntawm chromium nplua nuj poov xab

Chromium thiab lipid metabolism
Kev sib raug zoo ntawm chromium thiab lipid metabolism tau kawm ntau yam hauv tsev thiab thoob ntiaj teb: chromium supplementation tuaj yeem muaj txiaj ntsig kev tswj hwm thiab txhim kho cov txiaj ntsig ntawm lub cev lipid metabolism los ntawm kev tswj cov ntsiab lus ntawm ntau yam lipoproteins thiab cov roj cholesterol metabolism; Ntxiv cov tsiaj noj zaub mov nrog chromium tuaj yeem txo cov ntshav triglycerides thiab tag nrho cov roj cholesterol, thiab nce qib ntawm high-density lipoprotein (HDL). Chromium tuaj yeem tswj cov lipid metabolism los ntawm ob lub tswv yim. Ib qho yog tias kev noj zaub mov ntxiv ntawm chromium tuaj yeem ua rau cov tshuaj insulin nce ntxiv (uas txo qis thaum chromium tsis txaus thiab ua rau cov lipid metabolism tsis zoo los ntawm cov piam thaj metabolism), tswj cov lipid metabolism, thiab txhim kho lub cev cov ntshav lipid. Yog li ntawd, nws muaj feem xyuam rau qhov tshwm sim ntawm tib neeg cov kab mob plawv, hyperlipidemia, thiab arteriosclerosis; Qhov thib ob, chromium tuaj yeem txhim kho cov haujlwm ntawm lipoprotein lipase (LPL) thiab lecithin cholesterol acyltransferase (LCAT), uas ua lub luag haujlwm tseem ceeb hauv kev sib txuas ntawm HDL. Thaum lub cev tsis muaj chromium, cov synthesis thiab cov ntsiab lus ntawm HDL txo.
Qee cov pov thawj qhia tias chromium tuaj yeem ua rau kom tawg thiab tshem tawm cov roj cholesterol. Abraham et al. (1980) pom tau hais tias chromium tsis tsuas yog txo cov roj cholesterol hauv cov luav aorta, tab sis kuj tshem cov roj cholesterol tso rau ntawm lub aorta. Nplooj ntawv (1993) ntxiv ntau theem ntawm Picolinate Chromium rau kev noj zaub mov ntawm cov npua loj hlob thiab rog, txo qis cov roj cholesterol hauv cov ntshav npua. Lein (1996) ntxiv 200ppb ntawm chromium (GrPic) rau kev noj cov npua loj hlob, uas txo cov ntshav triglycerides thiab qis lipoprotein cholesterol (P<0.05), and significantly increased creatine liver and high-density lipoprotein (HDL) (P<0.05). Pahe et al. (1991) reported that adding 200pp chromium picolinate to the diet of laying hens resulted in a decrease in cholesterol in the blood, but no change in cholesterol in the egg yolk. Based on relevant research results, chromium may regulate lipid metabolism through two pathways. On the one hand, when animals are deficient in chromium, the biological activity of insulin decreases, glucose tolerance is impaired, and lipid metabolism disorders are caused by glucose metabolism. After chromium supplementation, insulin activity is enhanced, cholesterol deposition in the aorta is reduced, lipid metabolism is regulated, and lipid status is improved; On the other hand, chromium can enhance the activity of lipoproteins and lecithin cholesterol acyltransferase, thereby enhancing the synthesis of high-density lipoprotein. When animals lack chromium, the activity of these two enzymes decreases, leading to a decrease in high-density lipoprotein synthesis and a decrease in high-density lipoprotein in the blood.
Cov neeg laus muaj mob ntshav qab zib thiab atherosclerosis thaum lawv tsis muaj chromium, thiab tseem tuaj yeem ua rau hyperlipidemia, arterial Congee, kev loj hlob qeeb thiab luv luv lub neej. Chromium supplementation muaj cov nyhuv ntawm kev thim rov qab qhov tshwm sim saum toj no.
Cov nyhuv hypoglycemic ntawm chromium
Ntau cov kev tshawb fawb tau pom tias trivalent chromium hauv lub cev yuav ua rau cov piam thaj thiab lipid metabolism tsis meej. Chromium deficiency hauv tib neeg lub cev muaj feem cuam tshuam nrog ntshav qab zib thiab nws cov teeb meem. Nws ntseeg tau tias cov txheej txheem ntawm kev txiav txim ntawm chromium yog txhawm rau ua kom muaj kev sib raug zoo ntawm pancreatic beta receptors, nce tus naj npawb ntawm pancreatic beta receptors, thiab txhim kho cov phosphorylation ntawm pancreatic beta receptors. Tsis tas li ntawd, chromium feem ntau pab ua rau pancreatic islet tsis ua haujlwm hauv kev noj cov piam thaj, qabzib oxidation rau CO, thiab cov piam thaj hloov mus rau cov rog, nrog rau cov metabolism hauv cov suab thaj, cov protein, thiab cov rog nyob ntawm kev ua haujlwm ntawm pancreatic islet dysfunction. Lub luag haujlwm ntawm kev tshawb pom ntuj qis molecular hnyav chromium binding tshuaj (LMWCr) hauv kev tswj hwm pancreatic dysregulation yog maj mam lees paub. Chromium tuaj yeem qhib cov haujlwm ntawm insulin receptor kinase. Nyob rau hauv lub xub ntiag ntawm insulin kinase, LMWC tuaj yeem txhawb kev ua haujlwm kinase los ntawm 8 zaug. Txawm li cas los xij, cais chromium los ntawm nws yuav tshem tawm nws cov txiaj ntsig ntawm kev ua kom cov enzyme. Chromium tseem tuaj yeem cuam tshuam cov phosphorylation ntawm tyrosine phosphate
Phosphatase, uas tuaj yeem txo cov haujlwm ntawm pancreatic beta receptors.
Kev ua kom pancreatic beta kinase los ntawm chromium thiab inhibition ntawm pancreatic beta tyrosine phosphatase ua rau kom phosphorylation ntawm pancreatic beta kinase thiab nce rhiab heev rau pancreatic beta kinase.
Kev pom zoo txhua hnub chromium kom tsawg thoob ntiaj teb yog 50-200 micrograms. Cov kev tshawb fawb tau pom tias kev ntxiv chromium muaj txiaj ntsig zoo hauv kev kho mob ntshav qab zib hom 2 (xws li mob ntshav qab zib hom 2, ntshav qab zib hom 1, ntshav qab zib cev xeeb tub thiab steroid induced diabetes). Chromium deficiency muaj nyob rau hauv cov neeg mob ntshav qab zib. Cov nyhuv ntawm kev siv cov organic chromium zoo dua li inorganic chromium. Cov organic chromium muaj xws li chromium picolinate, chromium nicotinate, chromium poov xab, thiab lwm yam.