Kev faib tawm ntawm Zinc nplua nuj poov xab npaj

Zinc pab tau mus txog plaub theem. Thawj tiam ntawm zinc tshuaj uas thawj zaug tshwm sim yog inorganic ntsev xws li zinc sulfate thiab zinc chloride. Nws muaj cov qauv yooj yim, tus nqi qis, thiab cov khoom noj nruab nrab tuaj yeem tshem tawm cov tsos mob tshwm sim los ntawm zinc deficiency. Cov theem thib ob suav nrog ntau cov organic zinc ntxiv, xws li zinc gluconate, zinc glycyrrhizinate, zinc citrate, zinc lactate, thiab lwm yam. Qhov thib peb theem yog amino acid chelation ntawm zinc.
Inorganic Zinc
Xws li zinc sulfate, zinc oxide, zinc carbonate, zinc sulfide, thiab lwm yam. Tus neeg sawv cev ntawm inorganic zinc yog zinc sulfate, uas muaj cov qauv yooj yim thiab tus nqi qis. Kev noj tshuaj ntxiv tuaj yeem tshem tawm cov tsos mob tshwm sim los ntawm zinc deficiency. Raws li Suav Pharmacopoeia, qhov nqus ntawm tib neeg lub cev tsuas yog 7%. Vim nws cov tshuaj tiv thaiv kab mob plab acid, zinc chloride uas tsim tawm yog cov tshuaj lom corrosive, uas ua rau muaj kev cuam tshuam loj heev. Cov kab mob plab hnyuv muaj xws li txo qis qab los noj mov, xeev siab, ntuav, mob plab, raws plab, thiab lwm yam, uas tuaj yeem ua rau zinc lom.
Disadvantages ntawm inorganic zinc: a. Zinc muaj nyob rau hauv inorganic ion thiab yog ib qho nyuaj rau absorbed los ntawm tib neeg lub cev nyob rau hauv antagonistic cuam tshuam; b. Ib qho yooj yim tsim cov tshuaj insoluble nrog carbonic acid thiab phytic acid hauv cov nroj tsuag, cuam tshuam rau kev nqus; c. Nyob rau hauv nruab nrab ib puag ncig ntawm txoj hnyuv, inorganic zinc ntsev yog nquag hydrolysis; d. Nws muaj cov nyhuv stimulating ntawm lub plab thiab tej zaum yuav ua rau raws plab.
Organic synthesis ntawm zinc
Xws li zinc glycyrrhizinate, zinc oxalate, zinc citrate, zinc lactate, zinc glycyrrhizinate, thiab lwm yam. Piv nrog inorganic zinc, nws qhov tseem ceeb tshaj plaws feature yog tias nws cov nyhuv stimulating ntawm lub plab zom mov yog txo kom tsawg, thiab nws qhov ncauj nqus thiab siv tus nqi yog zoo dua piv rau cov uas tsis yog-polar zinc.
Cov zinc glycyrrhizic acid nyob rau hauv cov organic zinc yog ib yam khoom ntawm kev sib xyaw ntawm glycyrrhizic acid muab rho tawm los ntawm cov nroj tsuag licorice thiab zinc. Nws tso glycyrrhizic acid thiab zinc ions nyob rau hauv lub cev, thiab yog siv los ua ib qho tshuaj tiv thaiv kab mob ntawm qhov ncauj. Txawm li cas los xij, vim nws tus nqi siab, nws daim ntawv thov dav yog txwv. Zinc gluconate muaj cov ntsiab lus siab thiab nqus tau zoo, tab sis nws ua rau lub plab zom mov. Kev tswj qhov ncauj yuav ua rau mob xeev siab, ntuav, cem quav, thiab qee qhov kev ua xua rau lub plab mucosa. Tsis muaj qhov sib txawv tseem ceeb hauv qhov siab tshaj plaws tshuaj concentration thiab bioavailability ntawm zinc sulfate thiab zinc gluconate [1] noj los ntawm cov pejxeem, tab sis zinc gluconate absorbs sai dua, tswj kav ntev dua, thiab muaj siab tshaj qhov siab tshaj tshuaj concentration thiab bioavailability piv rau zinc sulfate. 2. Zinc lactate yog cov organic acid ntsev uas tau siv qhov ncauj los kho mob vwm. Nws muaj qhov nqus tau siab thiab tsis cuam tshuam los ntawm phytic acid thiab phytate ntsev. Raws li tsab ntawv ceeb toom [3], bioavailability ntawm zinc lactate nyob rau hauv kev sim nas yog kwv yees li 1.3-1.5 npaug ntawm zinc gluconate. Sun Guoping tau kawm cov tshuaj pharmacokinetics ntawm qhov ncauj zinc gluconate ntsiav tshuaj hauv cov neeg mob qog noj ntshav thiab pom tias nws muaj cov yam ntxwv ntawm kev nqus sai, siab ncov siab, thiab tshem tawm sai [4].
Txawm hais tias hom khoom no tau txhim kho qhov tsis zoo ntawm thawj tiam zinc ntsev, nws tseem muaj cov nyhuv antagonistic thiab tsawg nqus. Raws li Suav Phau Ntawv Txhais Lus ntawm Materia Medica, noj cov zinc tseem "feem ntau ua rau mob plab hnyuv xws li plab tsis xis nyob, xeev siab, thiab ntuav", thiab "kev siv txuas ntxiv yuav ua rau muaj kev phiv xws li potassium thiab sodium excretion, me edema". Kuj tseem muaj cov ntaub ntawv qhia tias nws cov bioavailability yog tsawg, tsuas yog li 14%. Tib neeg tab tom nrhiav kev tshawb fawb ntxiv thiab kev txhim kho ntawm nws cov bioavailability, tshuaj lom neeg tshwm sim, nqus, thiab cov txheej txheem metabolic.
Amino acid complex daim ntawv
Amino acid complexes yog thawj zaug tsim los ntawm American "Aibiwang" bio Laboratory. Thaum ntxov xyoo 1980, nws tau muag rau Tuam Tshoj thiab tam sim no nws tau tsim nyob rau hauv Suav teb. Ua ntej, cov protein hlau tau tsim los ntawm cov tsiaj cog cov proteins thiab cov hlau, thiab tom qab ua tiav cov txiaj ntsig zoo, nws tau raug txhawb nqa thiab tsim los tsim cov zinc amino acid complexes. Qhov no complex yog tsim los ntawm kev sib xyaw ntawm cov amino acids thiab hlau ntsiab xws li zinc nyob rau hauv tej yam txheej txheem.
Amino acid zinc muaj qhov sib txawv hauv chemistry thiab biochemistry piv rau inorganic zinc. Cov ntsiab lus hlau nyob rau hauv cov ntsev inorganic, xws li zinc sulfate, nkag mus rau hauv cov hnyuv hauv lub xeev ionic thiab hnov ​​​​mob nrog lwm cov ntsiab lus vim pH thiab ib puag ncig yam, dhau los ua cov tshuaj insoluble uas nyuaj rau zom thiab nqus. Amino acid zinc yog tsim los ntawm pawg carboxyl hauv cov amino acids thiab zinc ntsiab los tsim cov ntsev. Nyob rau tib lub sijhawm, nitrogen atom ntawm cov amino pawg hauv cov amino acids muaj ib qho tsis sib koom ua ke electron, uas tuaj yeem tsim kom muaj kev ruaj khov rau 6 lub nplhaib sib koom ua ke nrog zinc los ntawm kev sib koom ua ke, yog li muaj tshuaj lom neeg ruaj khov. Tsis tas li ntawd, cov amino acid zinc yog yooj yim absorbed thiab siv los ntawm tib neeg lub cev vim nws nruab nrab intramolecular nqi, solubility zoo nyob rau hauv lub pH ib puag ncig ntawm lub cev, thiab yooj yim tso tawm ntawm hlau ions. Cov tshuaj lom neeg ruaj khov ntawm qhov nyuaj no yog nruab nrab, thiab cov amino acids muaj kev tiv thaiv ntawm cov hlau ions, uas tuaj yeem tiv thaiv zinc los ntawm kev ua cov tshuaj insoluble hauv cov hnyuv los yog raug adsorbed ntawm insoluble colloids uas cuam tshuam lub nqus nqus, yog li pab txhawb kev nqus ntawm lub cev. Inorganic zinc xav tau cov cab kuj molecules rau encapsulate hlau ions thiab tsim ib qho organic lipid soluble complex sab nraum cell membrane thiaj li tso cai ions mus rau hauv lub cell membrane. Ntawm qhov tsis sib xws, tom qab nkag mus rau hauv lub cev, zinc amino acid complexes tuaj yeem thauj cov zinc ncaj qha mus rau cov ntaub so ntswg thiab cov enzymes raws li qhov sib txawv thiab qhov ntau ntawm qee cov amino acids xav tau los ntawm cov ntaub so ntswg sib txawv thiab cov enzymes. Zinc raug tso tawm los ntawm kev ua haujlwm ntawm cov enzymes thiab cov ntaub so ntswg kom tau raws li qhov xav tau ntawm lub cev. Qhov no tshem tawm qhov kev xav tau rau lub xeev kev loj hlob xav tau rau inorganic zinc, yog li kev txhim kho kev siv ntawm cov complex.
Hauv cov ntsiab lus, kev nqus thiab cov metabolism ntawm zinc amino acid complexes nyob rau hauv lub cev yog txawv los ntawm inorganic zinc, thiab qee cov zinc amino acid complexes tuaj yeem txhawb qee yam kev lom neeg. Txoj kev tshawb fawb ntawm kev tswj qhov ncauj ntawm zinc lysine thiab zinc sulfate hauv cov dev pom tias bioavailability ntawm zinc lysine yog ntau dua li zinc sulfate [5].
Txawm hais tias amino acid zinc muaj cov tshuaj lom neeg ruaj khov, zoo solubility hauv pH ib puag ncig ntawm lub cev, thiab tau yooj yim nqus thiab siv los ntawm tib neeg lub cev, kev tshawb fawb tsiaj tau pom tias [6]: thaum cov ntsiab lus ntawm calcium, phytic acid, thiab cellulose yog tsawg, qhov kev siv ntawm cov amino acid complex zinc tsis zoo dua li inorganic zinc. Thaum cov ntsiab lus ntawm zinc antagonist nyob rau hauv cov zaub mov yog siab, cov amino acid complex zinc tiv thaiv zinc los ntawm insoluble compounds nyob rau hauv lub plab hnyuv ib ntsuj av los yog los ntawm ncaj qha absorbed rau yaj colloids uas cuam tshuam kev nqus, yog li ua rau nws zoo heev biologically zoo. Qhov ntawd yog hais tias, nws bioavailability tsuas yog txhim kho qee qhov cuam tshuam ntawm cov zinc inorganic, tsis tas yuav nce nws cov tib neeg nqus tus nqi.